Why the study?
Does selective aldosterone receptor blockade reduce progressive renal dysfunction?
Does selective aldosterone receptor blockade reduce progressive renal dysfunction?
This review highlights emerging experimental evidence that aldosterone mediates progressive renal disease, providing a rationale for clinical trials of aldosterone receptor antagonists for renal protection.
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Hypothesis-generating for aldosterone antagonists in progressive renal disease; should not yet change clinical practice pending human trials.
Murray Epstein (2001) studied this question.
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