Why the study?
Does aldosterone antagonism offer additional antiproteinuric benefits in patients with renal disease treated with ACE inhibitors?
Population
Patients with intrinsic renal disease
Comparison
Mineralocorticoid receptor blockers added to… vs Angiotensin-converting enzyme inhibition alone
Design
Review
Authors
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Supports adjunctive aldosterone antagonism for proteinuria beyond ACE inhibition; leaves open hyperkalemia risks and hard outcomes.
Does aldosterone antagonism offer additional antiproteinuric benefits in patients with renal disease treated with ACE inhibitors?
Aldosterone antagonism provides additional antiproteinuric benefits beyond ACE inhibition in renal disease, though long-term safety data regarding hyperkalemia are needed.
Ibrahim et al. (2003) studied this question.
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