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November 1, 1998Journal of Biological ChemistryOpen Access

Molecular and Functional Characterization of a Calcium-sensitive Chloride Channel from Mouse Lung

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Population

Mouse lung cDNA library and human embryonic kidney cells (HEK293)

Design

Preclinical

Authors

RGRenu GandhiUniversidad Complutense de MadridRERandolph C. ElbleSouthern Illinois University School of MedicineAGAchim D. GruberTechnische Universität Berlin

Discussion

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Implication

Provides molecular candidate for Ca2+-activated Cl- currents; leaves open its role in cystic fibrosis pathogenesis.

Structured PICO

P
Population
Mouse lung cDNA library and human embryonic kidney cells (HEK293)
I
Intervention
Cloning and transient expression of mCLCA1 (calcium-sensitive chloride channel protein)
O
Outcome
Molecular and functional characterization of mCLCA1 (protein size, processing, localization, and chloride current)surrogate

The discovery and characterization of mCLCA1 provides a foundation for investigating the role of calcium-sensitive chloride conductance in the pathogenesis of cystic fibrosis.

Cite This Study

Gandhi et al. (1998) studied this question.

synapsesocial.com/papers/6a81b9f86f2d0f2f7d4cd8dfhttps://doi.org/10.1074/jbc.273.48.32096
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Also Consider

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