Why the study?
Does plasma concentration and acetylator phenotype determine the blood pressure response to oral hydralazine in hypertensive patients?
Does plasma concentration and acetylator phenotype determine the blood pressure response to oral hydralazine in hypertensive patients?
The blood pressure response to oral hydralazine is highly variable and depends on plasma concentration, which is significantly influenced by a patient's acetylator phenotype.
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Acetylator phenotype may influence hydralazine dosing needs due to marked PK variability; leaves open whether phenotype-guided therapy improves outcomes.
Shepherd et al. (1981) studied this question.
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