Key result
Women with PCOS had significantly lower adiponectin levels compared to controls (8.4 vs 13.6 ng/mL, P=0.00), an association that was dependent on vitamin D levels.
Why the study?
Is there an association between calcium and vitamin D deficiency and hypoadiponectinemia in women with PCOS?
Population
206 women (103 with polycystic ovary syndrome [PCOS] and 103 controls)
Design
Case-control
Authors
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Hypoadiponectinemia in PCOS was associated with vitamin D levels; hypothesis-generating and should not yet change practice.
Case-Control (n=206)
Is there an association between calcium and vitamin D deficiency and hypoadiponectinemia in women with PCOS?
Absolute Event Rate: 8.4% vs 13.6%
p-value: p=0.00
The association of hypoadiponectinemia with PCOS appears to be dependent on vitamin D levels, suggesting a potential metabolic benefit of vitamin D in this population.
Mazloomi et al. (2012) conducted a case-control in Polycystic Ovary Syndrome (n=206). Polycystic Ovary Syndrome vs. Controls was evaluated on Adiponectin concentration (ng/mL) (p=0.00). Women with PCOS had significantly lower adiponectin levels compared to controls (8.4 vs 13.6 ng/mL, P=0.00), an association that was dependent on vitamin D levels.
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