Key result
Low dose intravenous cangrelor resulted in no cases of symptomatic intracranial hemorrhage (0% vs 13%, p=0.54), demonstrating similar safety and efficacy to oral antiplatelets in acute ischemic stroke.
Why the study?
Neurointerventional procedures in acute ischemic stroke often require immediate antiplatelet therapy, and the study evaluated the safety and efficacy of intravenous cangrelor for urgent antiplatelet effect in these patients.
Does low dose intravenous cangrelor improve safety and efficacy compared to oral antiplatelets in patients with acute ischemic stroke requiring urgent antiplatelet effect?
Population
12 patients with acute ischemic stroke receiving intravenous cangrelor
Comparison
Intravenous cangrelor vs historical control group receiving oral dual antiplatelets
Design
Case series with historical control
Follow-up
90 days
Authors
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May support IV cangrelor feasibility in tandem occlusion thrombectomy; leaves open need for randomized confirmation of safety and outcomes.
Observational (n=35)
No
Does low dose intravenous cangrelor improve safety and efficacy compared to oral antiplatelets in patients with acute ischemic stroke requiring urgent antiplatelet effect?
Absolute Event Rate: 0% vs 13%
p-value: p=0.54
Low dose intravenous cangrelor appears safe and feasible as an acute antiplatelet strategy during mechanical thrombectomy for acute ischemic stroke, with no symptomatic intracranial hemorrhages observed in this small series.
Salahuddin et al. (2021) conducted an observational in Acute Ischemic Stroke (n=35). Intravenous cangrelor vs. Oral dual antiplatelets (aspirin and clopidogrel) was evaluated on Intracranial hemorrhage within 24 hours of starting cangrelor infusion (symptomatic ICH) (p=0.54). Low dose intravenous cangrelor resulted in no cases of symptomatic intracranial hemorrhage (0% vs 13%, p=0.54), demonstrating similar safety and efficacy to oral antiplatelets in acute ischemic stroke.
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