Why the study?
Spinal cord injury can cause autonomic dysreflexia with significant bradycardia due to loss of sympathetic tone, while cardioneural ablation of ganglionated plexi can treat arrhythmias dependent on excessive parasympathetic tone.
Does cardioneural ablation improve significant sinus bradycardia in a patient with spinal cord injury?
Case Report (n=1)
No
Does cardioneural ablation improve significant sinus bradycardia in a patient with spinal cord injury?
Cardioneural ablation is described as a potential treatment for significant sinus bradycardia in a patient with spinal cord injury.
Answers are grounded in this paper and cite their sources.
May offer option for refractory bradycardia in spinal cord injury; hypothesis-generating case report requiring prospective validation.
Cervical or high thoracic spinal cord injury (SCI) can cause autonomic dysreflexia with significant bradycardia.1 The destruction of the descending vasomotor pathways results in the loss of input to the sympathetic neurons and is currently considered the primary factor underlying the lack of sympathetic tone seen after high SCI.2 Ganglionated plexi (GP) consist of autonomic ganglia on the epicardial surface of the heart. Cardioneural ablation (CNA), ablation of the GP in the atria, has been described as a potential treatment of different arrhythmias that depend on excessive parasympathetic tone, including neurocardiogenic syncope,3 functional atrioventricular (AV) block,4 sinus dysfunction,5 and vagal-related atrial fibrillation.
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Lador et al. (2021) conducted a case report in Spinal cord injury with significant sinus bradycardia (n=1). Cardioneural ablation was evaluated on Heart rate improvement.
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