This review summarizes the physiological variables and systemic cellular behaviors regulating pathological calcification of bioprosthetic heart valves.
Biochemical, histological and genetic studies using in vitro/in vivo models have demonstrated that pathological calcification of bioprosthetic heart valves (BHV) is regulated by various mechanisms associated with physiological variables. The major objective of this review is to characterize physiological variables involved in BHV calcification. This review examines our understanding of the systemic cellular behavior and physiological regulation processes behind BHV calcification and its clinical applications.
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Chi H Lee (2009) studied this question.
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