December 1, 1990Clinical Chemistry

Insufficient accuracy and specificity of polyanion precipitation methods for quantifying low-density lipoproteins

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Structured PICO

Population

Lipid samples with varying concentrations of LDL, VLDL, HDL, and nonesterified fatty acids

Intervention

Polyanion precipitation assays (heparin, dextran sulfate, polyvinyl sulfate)

Outcome

Accuracy, specificity, and interference by nonesterified fatty acids in quantifying LDLsurrogate

Polyanion precipitation methods for LDL quantification demonstrate insufficient accuracy and specificity, highlighting limitations in their use for lipid profiling.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Clinicians should interpret LDL values from polyanion precipitation methods with caution; leaves open the accuracy of legacy lipid assays in research and practice.

Cite This Study

Siekmeier et al. (1990) studied this question.

synapsesocial.com/papers/6a81c7ee2ac899ae0206de12 https://doi.org/10.1093/clinchem/36.12.2109

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Implication

Clinicians should interpret LDL values from polyanion precipitation methods with caution; leaves open the accuracy of legacy lipid assays in research and practice.

Insufficient accuracy and specificity of polyanion precipitation methods for quantifying low-density lipoproteins

Structured PICO

Discussion

Implication

Cite This Study

Insufficient accuracy and specificity of polyanion precipitation methods for quantifying low-density lipoproteins

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider