This preclinical study demonstrates that capacitative Ca2+ entry in nonexcitable A549 cells can be regulated by caffeine/ryanodine-sensitive stores, expanding the understanding of intracellular calcium regulation.
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No immediate clinical implications from A549 cells; leaves open whether caffeine/ryanodine-sensitive stores regulate capacitative Ca2+ entry in human disease.
Xue et al. (2000) studied this question.
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