Key result
Target organ damage in hypertensive patients was associated with significantly increased systolic blood pressure variability, with aortic BPV providing no relevant additional information over brachial BPV.
Why the study?
Is short-term blood pressure variability associated with target organ damage in hypertensive patients?
Cross-Sectional (n=178)
Is short-term blood pressure variability associated with target organ damage in hypertensive patients?
Short-term blood pressure variability is increased in hypertensive patients with target organ damage, but aortic BPV does not provide additional information over brachial BPV.
Supports link between short-term BPV and target organ damage; leaves open causal role and value of aortic over brachial measures.
We aimed to evaluate the association of aortic and brachial short-term blood pressure variability (BPV) with the presence of target organ damage (TOD) in hypertensive patients. One-hundred seventy-eight patients, aged 57 ± 12 years, 33% women were studied. TOD was defined by the presence of left ventricular hypertrophy on echocardiogram, microalbuminuria, reduced glomerular filtration rate, or increased aortic pulse wave velocity. Aortic and brachial BPV was assessed by 24-hour ambulatory BP monitoring (Mobil-O-Graph). TOD was present in 92 patients (51.7%). Compared to those without evidence of TOD, they had increased night-to-day ratios of systolic and diastolic BP (both aortic and brachial) and heart rate. They also had significant increased systolic BPV, as measured by both aortic and brachial daytime and 24-hours standard deviations and coefficients of variation, as well as for average real variability. Circadian patterns and short-term variability measures were very similar for aortic and brachial BP. We conclude that BPV is increased in hypertensive-related TOD. Aortic BPV does not add relevant information in comparison to brachial BPV.
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Sierra et al. (2018) conducted a cross-sectional in Hypertension (n=178). Target organ damage (TOD) vs. Patients without evidence of TOD was evaluated on Association of aortic and brachial short-term blood pressure variability with the presence of target organ damage. Target organ damage in hypertensive patients was associated with significantly increased systolic blood pressure variability, with aortic BPV providing no relevant additional information over brachial BPV.
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