Key result
Transcatheter closure of small peri membranous ventricular septal defects in children significantly reduced median NT pro-BNP levels from 1.08 ng/ml to 0.91 ng/ml at 30 days.
Why the study?
Small VSD carries risks of adult ventricular dysfunction and other complications, leading to interest in using NT pro BNP to identify ventricular dilation and evaluate changes after transcatheter closure.
Does transcatheter closure reduce NT-proBNP levels in children with small peri membranous ventricular septal defects?
Observational (n=32)
Single-blind
Yes
Does transcatheter closure reduce NT-proBNP levels in children with small peri membranous ventricular septal defects?
Transcatheter closure of small peri membranous VSDs in children significantly reduces NT-proBNP levels and left ventricular end-diastolic diameter, suggesting relief of subtle left ventricular volume overload.
Answers are grounded in this paper and cite their sources.
Closure associated with NT-proBNP decline in small pmVSD; hypothesis-generating for volume overload relief, needs randomized outcome trials.
Background: Brain natriuretic peptide is a cardiac hormone secreted from the left ventricular myocardium due to ventricular expansion and volume overload. A recent study shows that small VSD will have risk of ventricular dysfunction in adulthood. Another complications such as endocarditis, congestive heart failure, aortic regurgitation, arrhythmia also we should be aware. Evaluations of the plasma B-type natriuretic peptide level (NT pro BNP) are currently being considered as methods to identify the possible presence of ventricular dilation in small VSD. Objective: To evaluate the change in plasma B-type natriuretic peptide after transcatheter closure of VSD. Methods: A pretest-posttest design was conducted on VSD patients before and after transcatheter closure. Plasma B-type natriuretic peptide level were measured before and 30 days after the transcatheter closure of VSD. Result: A total of 32 peri membranous VSD patients were included in this study with 62.5 % female patients (n=20) and 37.5 % male patients (n=12). A significant decrease was observed in the median NT pro BNP level when the level before closure of 1.08 (0.74 – 3.47) ng/ml was compared to the level after closure of 0.91 (0.68 – 2.07) ng/ml (p<0.05). Conclusion: Significant decreases in NT pro BNP level are seen in small VSD patients 30 days after transcatheter closure. Patients with small peri membranous VSD are generally considered to need occlusion for their childhood defect.
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Kuswiyanto et al. (2021) conducted an observational in Small peri membranous ventricular septal defect (pmVSD) (n=32). Transcatheter closure of VSD vs. Pre-procedure baseline was evaluated on Plasma NT pro-BNP level (ng/ml) (p=<0.001). Transcatheter closure of small peri membranous ventricular septal defects in children significantly reduced median NT pro-BNP levels from 1.08 ng/ml to 0.91 ng/ml at 30 days.
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