Key result
Percutaneous ASD closure linked to a ~52% drop in NT-proBNP, which correlates with RV volumes.
Why the study?
The role of NT-proBNP for estimating right heart failure and pulmonary pressure in patients with atrial septal defects before and after percutaneous closure was investigated.
Does NT-proBNP correlate with right heart hemodynamic parameters and volumes in patients with atrial septal defects before and after percutaneous closure?
Observational
Does NT-proBNP correlate with right heart hemodynamic parameters and volumes in patients with atrial septal defects before and after percutaneous closure?
Absolute Event Rate: 116% vs 240%
p-value: p=<0.01
NT-proBNP is a useful biomarker that correlates with right ventricular dilatation, pulmonary pressure, and left-to-right shunt in patients with ASD, and reflects hemodynamic improvement after percutaneous closure.
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NT-proBNP fell after ASD closure and correlated with RV volumes; leaves open biomarker-guided timing of intervention in shunt lesions.
Schoen et al. (2007) conducted an observational in Atrial septal defects (ASD). Percutaneous defect closure vs. Baseline (pre-closure) was evaluated on NT-proBNP levels (pg/ml) (p=<0.01). Percutaneous closure of atrial septal defects significantly reduced NT-proBNP levels from 240 to 116 pg/ml (p<0.01), and NT-proBNP positively correlated with right ventricular volumes (r=0.65).
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