Key result
NT-proBNP correlates with RVEF and RV volume but not LV function in acute PE.
Why the study?
The relative contribution of right ventricular function to NT-pro-BNP levels during acute pulmonary embolism was unclear despite NT-pro-BNP being a prognostic marker in PE.
Observational (n=339)
Effect estimate: β-coefficient -0.044 (95% CI ± -0.011)
p-value: p=<0.001
In patients with acute pulmonary embolism, NT-pro-BNP levels correlate with right ventricular dysfunction and dilation rather than left ventricular parameters, providing a pathophysiological basis for its prognostic value.
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NT-proBNP may signal RV dysfunction in acute PE; leaves open whether it refines risk stratification beyond imaging.
Klok et al. (2012) conducted an observational in Acute pulmonary embolism (n=339). Acute pulmonary embolism vs. Patients with clinically suspected but ruled out PE was evaluated on Correlation between right ventricular ejection fraction (RVEF) and NT-pro-BNP levels (β-coefficient -0.044, 95% CI ± -0.011, p=<0.001). In patients with acute pulmonary embolism, NT-pro-BNP levels significantly correlated with right ventricular ejection fraction (β=-0.044; p<0.001) and volume, but not left ventricular function.
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