Why the study?
Autonomic nervous system dysfunction may play a crucial role in chronic cancer-related pain, fatigue, and neuropathy, but the association of heart rate variability with these symptoms needed systematic assessment.
Does heart rate variability predict fatigue, pain, and neuropathic symptoms in cancer patients and survivors?
Population
19 studies of cancer patients and survivors
Comparison
Heart rate variability measures in relation to pain, fatigue, and neuropathy
Design
Systematic review
Authors
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Low-quality evidence links reduced HRV to cancer-related fatigue and pain; leaves open standardized validation before any clinical use.
Does heart rate variability predict fatigue, pain, and neuropathic symptoms in cancer patients and survivors?
Decreased heart rate variability appears to be associated with increased cancer-related fatigue and pain, suggesting autonomic dysfunction plays a role in these symptoms, though standardized protocols are needed for validation.
Bolanos et al. (2025) studied this question.
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