Key result
Cancer patients exhibited reduced heart rate variability compared to reference individuals, including a lower SDNN, indicating autonomic dysfunction.
Why the study?
A significant proportion of cancer patients experience autonomic dysfunction, and cancer treatments can exacerbate cardiac autonomic nervous system impairments.
Do cancer patients have altered heart rate variability compared to reference individuals?
Observational (n=127)
No
Do cancer patients have altered heart rate variability compared to reference individuals?
Cancer patients exhibit significantly abnormal heart rate variability, suggesting the presence of cardiac autonomic dysfunction.
Answers are grounded in this paper and cite their sources.
Reduced HRV signals possible autonomic dysfunction in cancer; leaves open prognostic value and monitoring utility.
BACKGROUND: A significant proportion of cancer patients experience autonomic dysfunction, and cancer treatments such as chemotherapy and radiation therapy can exacerbate impairments in the cardiac autonomic nervous system. This study sought to investigate the characteristics of heart rate variability (HRV) in individuals with cancer. AIM: To evaluate the relationship between HRV and cancer patients, providing insights and references for cancer treatment. METHODS: The study included 127 cancer patients with available 24-hour dynamic electrocardiogram data. HRV differences were analyzed using both time domain and frequency domain methods. These findings were then compared to HRV data from reference individuals, sourced from literature that utilized the same HRV computing algorithm. CONCLUSION: This study indicates that cancer patients have significantly abnormal HRV compared to reference individuals, suggesting the presence of a certain level of cardiac autonomic dysfunction in this patient population.
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Bing Song (2025) conducted an observational in Cancer (n=127). Cancer vs. Healthy reference individuals (from literature) was evaluated on SDNN (Standard deviation of all normal-to-normal intervals) (p=< 0.05). Cancer patients exhibited reduced heart rate variability compared to reference individuals, including a lower SDNN, indicating autonomic dysfunction.
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