Why the study?
The pathogenetic and clinical relationship between degenerative aortic stenosis and aortic stiffness is poorly known.
Does aortic stiffness predict prognosis and outcomes of valve replacement in patients with degenerative aortic stenosis?
Does aortic stiffness predict prognosis and outcomes of valve replacement in patients with degenerative aortic stenosis?
Aortic stiffness parameters, particularly pulse wave velocity, show potential as prognostic biomarkers for risk stratification and predicting outcomes after aortic valve replacement in degenerative aortic stenosis.
May support post-replacement risk stratification in aortic stenosis; hypothesis-generating and requires prospective validation.
Aortic stenosis (AS) is one of the most common cardiovascular diseases. The prevalence of AS and vascular stiffness are significantly associated with age. Elevated arterial stiffness is an independent risk factor for cardiovascular events. The pathogenetic and clinical relationship of degenerative AS and aortic stiffness is poorly known. This review reflects the current understanding of the relationship between degenerative AS and aortic stiffness. The existing evidence on the effects of surgical and endovascular correction of the defect on aortic stiffness is described. The potential predictors of AS prognosis and outcomes of valve replacement are discussed. Unresolved issues and directions for further research are clarified.
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Протасов et al. (2021) studied this question.
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