Key result
Arterial stiffness evaluation yields conflicting post-TAVR results, highlighting the need for validated pre-TAVR risk indices.
Why the study?
Degenerative AS and elevated arterial stiffness frequently coexist, but studies examining arterial stiffness following TAVR have yielded conflicting results.
Accurately evaluating pulsatile LV load and arterial stiffness in severe AS may be instrumental in pre-TAVR risk assessment.
Arterial stiffness assessment may refine LV load evaluation in severe AS; leaves open optimal integration into TAVR planning and response prediction.
In an ageing population, degenerative aortic stenosis (AS) and elevated arterial stiffness frequently coexist, imposing a combined valvular and pulsatile arterial afterload on the left ventricle (LV). Since the significance of arterial stiffness in the setting of AS is becoming increasingly recognised, there is greater emphasis on accurately evaluating this pulsatile LV load in the presence of severe AS and predicting the arterial response post transcatheter aortic valve replacement (TAVR). To date, studies examining arterial stiffness in AS following TAVR have yielded conflicting results. This review aims to comprehensively evaluate measures of arterial stiffness and pulsatile LV load in the presence of AS. We summarise existing evidence on the interplay between AS and arterial stiffness while identifying current gaps in our understanding of this interaction. Future studies to validate a non-invasive index for pulsatile arterial load in AS may prove instrumental in pre-TAVR risk assessment.
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Song et al. (2026) conducted a review in Aortic stenosis and elevated arterial stiffness. Evaluating arterial stiffness in aortic stenosis reveals conflicting post-TAVR results, highlighting the need to validate non-invasive indices for pulsatile arterial load in pre-TAVR risk assessment.
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