June 1, 2005Hypertension
Diabetic Neuropathy Is a More Important Determinant of Baroreflex Sensitivity Than Carotid Elasticity in Type 2 Diabetes
Why the study?
Is diabetic neuropathy a more important determinant of baroreflex sensitivity than carotid elasticity in patients with type 2 diabetes?
Population
139 subjects: 79 consecutive patients with type 2 diabetes mellitus with at least 2 additional…
Comparison
Presence of type 2 diabetes and peripheral… vs Matched subjects without diabetes
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May prioritize neuropathy assessment in diabetic baroreflex evaluation; hypothesis-generating and requires prospective validation.
Structured PICO
Is diabetic neuropathy a more important determinant of baroreflex sensitivity than carotid elasticity in patients with type 2 diabetes?
P
Population
139 subjects: 79 consecutive patients with type 2 diabetes mellitus with at least 2 additional cardiovascular risk factors, and 60 matched subjects without diabetes.
I
Intervention
Presence of type 2 diabetes and peripheral neuropathy (observational exposure)
C
Comparator
Matched subjects without diabetes
O
Outcome
Spontaneous baroreflex sensitivity assessed using time and frequency methodssurrogate
In patients with type 2 diabetes, peripheral neuropathy is a more significant determinant of impaired baroreflex sensitivity than carotid artery elasticity.
Cite This Study
Ruiz et al. (2005) studied this question.