Prescription Rates of Guideline‐Directed Medications Are Associated With In‐Hospital Mortality Among Japanese Patients With Acute Myocardial Infarction: A Report From JROAD‐DPC Study
Why the study?
The study aimed to investigate the relationship between hospital prescription rates of guideline-directed medications and in-hospital mortality among patients with acute myocardial infarction.
Does a higher hospital-level prescription rate of guideline-directed medications reduce in-hospital mortality in patients with acute myocardial infarction?
Population
61 838 Japanese patients with acute myocardial infarction from 741 hospitals
Comparison
Prescription rate quartiles of 4 guideline-directed medications across hospitals
Design
Nationwide claims database study
Authors
Discussion
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Member takes
Implication
Supports targeting higher hospital GDMT rates in AMI; observational data leaves causality open.
Structured PICO
Does a higher hospital-level prescription rate of guideline-directed medications reduce in-hospital mortality in patients with acute myocardial infarction?
P
Population
61,838 Japanese patients from 741 hospitals with acute myocardial infarction between 2012 and 2013
I
Intervention
Highest prescription rate quartile of guideline-directed medications (aspirin, beta-blockers, ACEi/ARB, statins)
C
Comparator
Lowest prescription rate quartile of guideline-directed medications
O
Outcome
In-hospital mortalityhard clinical
Higher hospital-level prescription rates of guideline-directed medical therapy for acute myocardial infarction are significantly associated with lower in-hospital mortality.
Cite This Study
Nakao et al. (2019) studied this question.