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January 1, 2001Cerebrovascular Diseases

Clinically asymptomatic hemorrhagic infarctions type I/II/III were detected in 4/1/1 patients of the tirofiban group versus 4/2/0 controls (OR = 0.92; 95% CI 0.4-2.5), with no major intracranial hemorrhage in either group.

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Why the study?

Does intravenous tirofiban increase the risk of cerebral hemorrhage in patients with progressively deteriorating acute ischemic stroke?

Population

35 patients total: 18 with progressively deteriorating acute ischemic stroke and 17 matched acute ischemic…

Comparison

Body-weight adjusted intravenous tirofiban for a… vs Matched group of acute ischemic clinically…

Design

Cohort, Open-label

Follow-up

6-10 days after symptom onset

Authors

UJUlrich JunghansRSRüdiger J. SeitzAAA. Aulich

Discussion

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Overview

Tirofiban was not associated with increased hemorrhage in this cohort; hypothesis-generating and supports randomized trials before any practice change.

Structured PICO

Does intravenous tirofiban increase the risk of cerebral hemorrhage in patients with progressively deteriorating acute ischemic stroke?

P
Population
35 patients total: 18 with progressively deteriorating acute ischemic stroke and 17 matched acute ischemic clinically stable stroke patients.
I
Intervention
Body-weight adjusted intravenous tirofiban for a mean period of 46 hours.
C
Comparator
Matched group of acute ischemic clinically stable stroke patients.
O
Outcome
Rate of hemorrhagic transformation and major bleedings assessed by cranial imaging 6-10 days after symptom onset.safety

Intravenous tirofiban was not associated with a significantly increased cerebral bleeding rate in patients with acute ischemic stroke, supporting the feasibility of further randomized trials.

Limitations

  • Not a randomized multicenter study (pilot design)

Cite This Study

Junghans et al. (2001) studied this question.

synapsesocial.com/papers/6a81e1f25bcfff97abe03f8dhttps://doi.org/10.1159/000047726
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Treatment of Progressive Stroke with Tirofiban – Experience in 35 Patients2009 · 41 citations
  2. 2Efficacy and Safety of Tirofiban for the Management of Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials (RCTs)2026
  3. 3Abstract TP060: Evaluation of the Satety Profile of the Tirofiban Protocol for Select Patients with Acute Ischemic Stroke at a United States Comprehensive Stroke Center2026
  4. 4Tirofiban: an investigational plateletglycoprotein IIb/IIIa receptor antagonist1997 · 18 citations
  5. 5Safety and efficacy of tirofiban in the management of stroke: A systematic review and meta-analysis of randomized controlled trials2023 · 20 citations