Why the study?
Does platelet depletion or dysfunction affect angiogenesis and hemorrhage in vivo?
Population
8- to 12-week-old, age-matched C57BL/6J, C57BL/6J-Lystbg, FcgammaR, and GPIbalpha/IL4R transgenic mice
Comparison
Platelet depletion via antiplatelet antibody or… vs Control IgG injection or wild-type (WT) mice
Design
Preclinical, Blinded observer for hemorrhagic score and platelet adhesion…
Follow-up
Up to 7 days
Authors
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Animal data on platelet effects in cornea leave open any role in human angiogenesis or antiplatelet safety.
Does platelet depletion or dysfunction affect angiogenesis and hemorrhage in vivo?
Platelets and their adhesive function, mediated by GPIbalpha, are critical for stimulating angiogenic vessel growth and preventing excessive hemorrhage from newly formed vessels.
Kisucka et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: