Key result
Thrombocytopenia or inhibition of platelet aggregation resulted in about 35-50% reduction of retinal neovascularization in a mouse model of hypoxia-induced angiogenesis.
Population
Mouse model of hypoxia-induced retinal angiogenesis and in vitro microvascular endothelial cells
Design
Preclinical
Authors
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Hypothesis-generating for antiplatelet inhibition in retinal angiogenesis; leaves open translation to human disease.
Blood platelets play a significant proangiogenic role in neovascularization, suggesting that anti-platelet substances may act as potent inhibitors of angiogenesis.
Fischer et al. (2004) studied Hypoxia-induced retinal angiogenesis. Thrombocytopenia or platelet aggregation inhibitors (alphaIIbbeta3-integrin antagonist, Aspirin) was evaluated on Retinal neovascularization. Thrombocytopenia or inhibition of platelet aggregation resulted in about 35-50% reduction of retinal neovascularization in a mouse model of hypoxia-induced angiogenesis.
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