[OAS1 gene polymorphism is associated with central nervous system involvement in children with enterovirus 71 infection].

OBJECTIVE: gene polymorphism and susceptibility to central nervous system (CNS) involvement of enterovirus (EV)71 infection. METHODS: rs2660 and rs1131454 were analyzed using SNPscan multiple SNP typing methods. RESULTS: rs2660 polymorphism was significantly different between the children with CNS involvement and those with mild EV71 infection, and the genotype AG frequency was higher and the genotype GG frequency was lower in children with CNS involvement. No significant difference was found in the distribution of genotypes or alleles of rs1131454 between the children with CNS involvement and those with mild EV71 infection. CONCLUSIONS: rs2660 AG genotype are more likely to have CNS involvement after EV71 infection.