Key result
The TMEM173 rs7447927 G allele and GG genotype were significantly associated with increased susceptibility to and severity of EV71 infection in Chinese children.
Why the study?
The association between the TMEM173 polymorphism (rs7447927) and the severity of enterovirus 71 infection among Chinese children was unknown.
Is the TMEM173 rs7447927 polymorphism associated with susceptibility to and severity of enterovirus 71 infection in Chinese children?
Case-Control (n=1,032)
Is the TMEM173 rs7447927 polymorphism associated with susceptibility to and severity of enterovirus 71 infection in Chinese children?
The TMEM173 rs7447927 polymorphism (G allele and GG genotype) is associated with increased susceptibility to and severity of EV71 infection in Chinese children.
GG genotype of rs7447927 was associated with severe EV71; hypothesis-generating for genetic risk stratification in Chinese children.
INTRODUCTION: This study was designed to explore the association between the TMEM173 polymorphism (rs7447927) and the severity of enterovirus 71 (EV71) infection among Chinese children. METHODS: The TMEM173 polymorphism was identified in EV71-infected patients (n = 497) and healthy controls (n = 535) using the improved multiplex ligation detection reaction (iMLDR). The interferon-α (IFN-α) serum levels were detected using enzyme linked immunosorbent assay (ELISA). RESULTS: The frequencies of the GG genotype and G allele of TMEM173 rs7447927 in the mild EV71 infection and severe EV71 infection groups were markedly higher than those in the control group. The GG genotype and G allele frequencies in severely infected EV71 patients were significantly higher than those in mildly infected EV71 patients. Severely infected EV71 patients with the GG genotype had higher white blood cell counts (WBC), and C-reactive proteins (CRP), and blood glucose (BG) levels, longer fever duration, higher vomiting frequency, spirit changes, and electroencephalography (EEG) abnormalities. IFN-α serum concentration in severely infected patients was significantly higher than in the mildly infected group. The IFN-α concentration in the GG genotype was significantly higher compared with those in the GC and CC genotypes in severe cases. CONCLUSIONS: The TMEM173 rs7447927 polymorphism was associated with EV71 infection susceptibility and severity. The G allele and GG genotype are susceptibility factors in the development of severe EV71 infection in Chinese children.
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Song et al. (2022) conducted a case-control in Enterovirus 71 (EV71) infection (n=1,032). TMEM173 rs7447927 genetic polymorphism vs. Healthy controls and mildly infected patients was evaluated on Susceptibility to and severity of EV71 infection. The TMEM173 rs7447927 G allele and GG genotype were significantly associated with increased susceptibility to and severity of EV71 infection in Chinese children.
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