Oxymorphone was converted to naltrexone in three steps by palladium‐catalyzed oxidative N ‐demethylation and intramolecular acyl transfer from C‐14 hydroxy to N‐17. Vitride™ reduction of N ‐acylamide to N ‐alkylamine proceeded with concomitant reductive deprotection of C‐6 and O‐3 functionalities.
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Machara et al. (2012) studied this question.
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