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Summarize recent advances in the structural modification of 5-fluorouracil to develop novel derivatives with improved anticancer efficacy and reduced toxicity.

September 9, 2011Current Medicinal Chemistry

Development of 5-Fluorouracil Derivatives as Anticancer Agents

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XPXiaoyan PanHunan University of Traditional Chinese Medicine CWChen WangNational Institutes of Health FWFang WangKunming University of Science and Technology

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Implication

Review reveals progress in designing 5-fluorouracil derivatives for solid tumors, indicating improved antitumor efficacy with reduced systemic toxicity.

Key Points

Summarize recent advances in the structural modification of 5-fluorouracil to develop novel derivatives with improved anticancer efficacy and reduced toxicity.
Reviewed literature regarding chemical modifications of the 5-fluorouracil (5-FU) pyrimidine scaffold.
Evaluated emerging classes of 5-FU derivatives, including macromolecule and polymer conjugates designed for solid tumor therapy.
Structural modifications of 5-FU successfully generate novel derivatives displaying heightened antitumor potency against advanced solid tumors.
Engineered derivatives exhibit substantially diminished systemic toxicity compared to native 5-FU.

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Pan et al. (2011) studied this question.

synapsesocial.com/papers/6a81f032e5ad2a206e4d53bd https://doi.org/10.2174/092986711797287584

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Implication

Review reveals progress in designing 5-fluorouracil derivatives for solid tumors, indicating improved antitumor efficacy with reduced systemic toxicity.

Development of 5-Fluorouracil Derivatives as Anticancer Agents

Discussion

Member takes

Implication

Key Points

Cite This Study

Development of 5-Fluorouracil Derivatives as Anticancer Agents

Discussion

Member takes

Implication

Key Points

Cite This Study

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