In vitro studies of dog renal cortical slices demonstrate that both sodium and calcium ions regulate renin release at the cellular level.
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Supports ionic modulation of renin in canine slices; hypothesis-generating for human juxtaglomerular physiology and should not change practice.
A preparation of dog renal cortical slices suitable for the study of renin release was utilized to study the effect of sodium and calcium ions on the release of this enzyme. An inverse relationship was found between renin release and sodium concentration in the incubation medium. When calcium ion concentration in the incubation medium was the only variable renin release increased with calcium and reached optimal level at around 2.5 mM calcium. The omission of calcium markedly inhibited renin release. The results suggest that both sodium and calcium ions may play a role in the release of renin at the cellular level.
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Andrew M. Michelakis (1971) studied this question.
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