Why the study?
Does adenovirus vector-mediated gene transfer of thrombomodulin improve thromboresistance and reduce neointima formation in autologous rabbit vein grafts?
Population
Autologous rabbit vein graft model
Comparison
Adenovirus vector-mediated gene transfer to… vs Normal veins and untreated vein grafts
Design
Preclinical
Follow-up
up to 42 days
Authors
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TM restoration normalizes early thrombin activity without curbing neointima in rabbit grafts; leaves open whether targeted TM therapies can improve clinical bypass outcomes.
Does adenovirus vector-mediated gene transfer of thrombomodulin improve thromboresistance and reduce neointima formation in autologous rabbit vein grafts?
Early loss of thrombomodulin expression impairs vein graft thromboresistance and increases local thrombin generation, but restoring it does not prevent late neointimal hyperplasia.
Kim et al. (2002) studied this question.
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