Why the study?
Does gender influence cardiac function in the mdx mouse model of Duchenne cardiomyopathy?
Population
22-month-old male and female mdx mice (model of Duchenne cardiomyopathy)
Comparison
Female gender vs Male gender
Design
Preclinical
Authors
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Sex must be controlled in mdx cardiomyopathy studies; leaves open whether female predominance translates to human Duchenne patients.
Does gender influence cardiac function in the mdx mouse model of Duchenne cardiomyopathy?
Female mdx mice exhibit more severe cardiac dysfunction and dilation than males at 22 months, highlighting a significant gender disparity that should be considered when using this model for Duchenne cardiomyopathy.
Yue et al. (2010) studied this question.
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