Key result
Female mdx mice showed better-preserved specific tetanic force at 6 months of age and stiffer muscle at 20 months of age compared to male mdx mice.
Answers are grounded in this paper and cite their sources.
Gender profoundly influences physiological measurement outcomes in mdx mice, highlighting the need to account for sex differences in preclinical Duchenne muscular dystrophy studies.
INTRODUCTION: Duchenne muscular dystrophy (DMD) is a severe, muscle-wasting disease caused by mutations in the dystrophin gene. The mdx mouse is the first and perhaps the most commonly used animal model for study of DMD. Both male and female mdx mice are used. However, it is not completely clear whether gender influences contraction and the passive mechanical properties of mdx skeletal muscle. METHODS: We compared isometric tetanic forces and passive forces of the extensor digitorum longus muscle between male and female mdx mice. RESULTS: At age 6 months, female mdx mice showed better-preserved specific tetanic force. Interestingly, at 20 months of age, female mdx muscle appeared stiffer. CONCLUSIONS: Our results suggest that gender may profoundly influence physiological measurement outcomes in mdx mice.
No takes yet. Share an insight, caveat, or question.
Hakim et al. (2011) studied Duchenne muscular dystrophy (mdx mouse model). Female sex vs. Male sex was evaluated on Isometric tetanic forces and passive forces of the extensor digitorum longus muscle. Female mdx mice showed better-preserved specific tetanic force at 6 months of age and stiffer muscle at 20 months of age compared to male mdx mice.
Synapse has enriched 10 related papers. Consider them for comparative context: