June 1, 1991The Journal of PhysiologyOpen Access

Spontaneous and noradrenaline‐induced transient depolarizations in the smooth muscle of guinea‐pig mesenteric vein.

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Population

Guinea-pig mesenteric vein smooth muscle

Comparison

Noradrenaline stimulation, caffeine, cobalt… vs Baseline (before stimulation)

Design

Preclinical

Authors

DHDirk van HeldenElectrophysiology

Discussion

Member takes

Implication

Does not support clinical changes in vascular tone management; leaves open translation of chloride-dependent ASTDs to human physiology.

Structured PICO

Population

Guinea-pig mesenteric vein smooth muscle (short segments of small veins, diameter <150 microns, length <250 microns)

Intervention

Noradrenaline (NA) stimulation, caffeine, cobalt solution, and low-chloride solution

Comparator

Baseline (before stimulation)

Outcome

Membrane current recordings (spontaneous transient depolarizations [STDs] and underlying inward currents [STICs])surrogate

This preclinical study characterizes the electrophysiological properties of spontaneous and noradrenaline-induced transient depolarizations in guinea-pig mesenteric vein smooth muscle, highlighting their myogenic origin and chloride dependence.

Cite This Study

Dirk van Helden (1991) studied this question.

synapsesocial.com/papers/6a81f5035639d4e07ebf65f6 https://doi.org/10.1113/jphysiol.1991.sp018609

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