July 6, 2023BiomedicinesOpen Access

Platelet Adhesion Mediated by von Willebrand Factor at High Shear Rates Is Associated with Premature Coronary Artery Disease

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Why the study?

This study investigated von Willebrand factor-mediated platelet adhesion at high shear rates in patients with premature coronary artery disease.

Is VWF-mediated platelet adhesion at high shear rates associated with premature coronary artery disease?

Population

84 patients with stable premature CAD and 64 patients without CAD

Comparison

Patients with stable premature CAD vs patients without CAD

Authors

SOSergey OkhotaNational Medical Research Center of Cardiology SKSergey KozlovNational Medical Research Center of Cardiology YAYuliya AvtaevaNational Medical Research Center of Cardiology

Discussion

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Implication

Enhanced GPIb-mediated adhesion associated with premature CAD; hypothesis-generating and requires prospective validation before clinical consideration.

Structured PICO

Is VWF-mediated platelet adhesion at high shear rates associated with premature coronary artery disease?

Population

148 patients, comprising 84 patients with stable premature coronary artery disease (CAD) and 64 patients without CAD.

Intervention

In vitro assessment of whole blood samples perfused through a microfluidic cell over a collagen-coated surface at a high shear rate (1300 s−1), with inhibition of VWF-specific platelet GPIb receptors using an anti-GPIb monoclonal antibody (mAb).

Comparator

Patients without CAD (control group) and baseline measurements before anti-GPIb mAb inhibition.

Outcome

Decrease in platelet adhesion after the inhibition of VWF-platelet interaction with anti-GPIb mAb.surrogate

GPIb-mediated platelet adhesion is significantly more pronounced in patients with premature CAD, suggesting that excessive VWF-platelet interactions may play a role in the development of premature CAD.

Cite This Study

Okhota et al. (2023) studied this question.

synapsesocial.com/papers/6a81fd57d433ecbb06e1eeb3 https://doi.org/10.3390/biomedicines11071916

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Implication

Enhanced GPIb-mediated adhesion associated with premature CAD; hypothesis-generating and requires prospective validation before clinical consideration.

Platelet Adhesion Mediated by von Willebrand Factor at High Shear Rates Is Associated with Premature Coronary Artery Disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Platelet Adhesion Mediated by von Willebrand Factor at High Shear Rates Is Associated with Premature Coronary Artery Disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider