Population
Normal rat hearts (cross-circulated rat heart preparations)
Comparison
Recombinant adenoviral vector carrying… vs Saline or baseline before infusion
Design
Preclinical
Follow-up
30-90 minutes (ex vivo) and 3 days (in vivo)
Authors
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Supports vector safety in healthy rat hearts; leaves open translation to diseased models or clinical gene therapy.
Adenoviral gene transfer using Ad.betagal-GFP does not impair left ventricular mechanical or energetic function in normal rat hearts, supporting its safety for targeted gene therapy.
Sakata et al. (2007) studied this question.
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