Key result
Adenoviral gene transfer in isolated rabbit myocardium achieved high-level transgene expression without adverse effects on contractile function after 48 hours.
Population
Rabbit hearts subjected to an ex vivo perfusion protocol to achieve gene transfer in >90% of cardiac myocytes.
Comparison
Adenoviral gene transfer. vs Sham-infected hearts.
Design
Preclinical
Follow-up
48 hours
Authors
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Supports ex vivo feasibility in rabbit models without functional harm; leaves open in vivo or clinical translation.
Absolute Event Rate: 15.3% vs 17%
Ex vivo adenoviral gene transfer in isolated rabbit myocardium achieves high-level gene expression without adverse effects on contractile function over 48 hours.
Lehnart et al. (2000) studied Isolated myocardium (n=33). Adenoviral gene transfer vs. Sham infection was evaluated on Contractile function (developed force) after 48 hours. Adenoviral gene transfer in isolated rabbit myocardium achieved high-level transgene expression without adverse effects on contractile function after 48 hours.
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