Population
Adult rat ventricular myocytes isolated from male Sprague-Dawley rats weighing 250-300 g
Comparison
Replication-deficient adenovirus type 5… vs Uninfected cells and cells infected with control…
Design
Preclinical
Follow-up
48 hours
Authors
Loading...
May enable efficient in vitro cardiac gene transfer studies; leaves open in vivo translation and clinical relevance.
Recombinant adenovirus provides a highly efficient method for gene transfer into adult ventricular myocytes in culture without altering cell viability or morphology.
Kirshenbaum et al. (1993) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: