What question did this study set out to answer?

To describe a case of mobile left ventricular apical thrombus formation and subsequent transient ischemic attack complicating suspected tako-tsubo-like left ventricular dysfunction.

January 1, 2003Circulation JournalOpen Access

Left Ventricular Apical Thrombus Formation in a Patient With Suspected Tako-Tsubo-Like Left Ventricular Dysfunction

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To describe a case of mobile left ventricular apical thrombus formation and subsequent transient ischemic attack complicating suspected tako-tsubo-like left ventricular dysfunction.
Evaluated a 74-year-old female presenting with chest discomfort and acute right hemiparesis.
Performed electrocardiography, coronary angiography, left ventriculography, and coagulation factor assays.
Initiated oral anticoagulant therapy with warfarin and monitored thrombus resolution.
Left ventriculography confirmed severe apical hypokinesis with a mobile 4 x 4-mm apical thrombus despite the absence of significant coronary artery stenosis.
Laboratory testing revealed decreased activity levels for both protein C and protein S.
Anticoagulation therapy with warfarin resulted in the complete resolution of the intracardiac thrombus after 2 weeks.

Structured PICO

Population

A 74-year-old woman with hypertension, bronchial asthma, and suspected tako-tsubo-like left ventricular dysfunction presenting with a transient cerebral ischemic attack (n=1).

Intervention

Anticoagulant treatment with warfarin for 2 weeks.

Outcome

Disappearance of the left ventricular thrombus.surrogate

Tako-tsubo-like left ventricular dysfunction can be complicated by left ventricular apical thrombus formation leading to embolic events, which may resolve with short-term warfarin therapy.

Discussion

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Implication

Short-term warfarin resolution of apical thrombus in this case should not change practice; leaves open anticoagulation role in tako-tsubo cardiomyopathy.

Cite This Study

Kurisu et al. (2003) studied this question.

synapsesocial.com/papers/6a81fe902f94e177df06deff https://doi.org/10.1253/circj.67.556

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Implication

Short-term warfarin resolution of apical thrombus in this case should not change practice; leaves open anticoagulation role in tako-tsubo cardiomyopathy.

Left Ventricular Apical Thrombus Formation in a Patient With Suspected Tako-Tsubo-Like Left Ventricular Dysfunction

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Left Ventricular Apical Thrombus Formation in a Patient With Suspected Tako-Tsubo-Like Left Ventricular Dysfunction

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider