Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY‐5445, vinpocetine and 1‐methyl‐3‐isobutyl‐8‐(methylamino)xanthine

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Population

Rat aorta tissue

Design

Preclinical

Authors

Discussion

Animal data on cGMP PDE inhibitors require human validation; leaves open therapeutic translation.

Population

Rat aorta tissue

Intervention

M&B 22,948, MY-5445, vinpocetine, and 1-methyl-3-isobutyl-8-(methylamino)xanthine (MIMAX)

Outcome

Inhibition of cyclic nucleotide phosphodiesterases (PDEs), cyclic GMP/AMP accumulation, and smooth muscle relaxationsurrogate

The smooth muscle relaxant actions of M&B 22,948 and MIMAX in rat aorta are mediated through the inhibition of cyclic GMP hydrolysis.

Souness et al. (1989) studied this question.

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