Why the study?
Does PRR blockade or valsartan reduce renal inflammation and albuminuria in a rat model of diabetic nephropathy?
Population
Normoglycaemic control and streptozotocin-diabetic Sprague-Dawley rats
Comparison
PRR blocker, valsartan, or combined therapy… vs Untreated diabetic rats and normoglycaemic…
Design
Preclinical
Follow-up
14 days
Authors
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Supports PRR as a target in diabetic nephropathy models; leaves open translation to human disease.
Does PRR blockade or valsartan reduce renal inflammation and albuminuria in a rat model of diabetic nephropathy?
PRR blockade reduces renal inflammation and albuminuria in diabetic rats independently of renal AngII effects, suggesting a role for PRR in diabetic nephropathy.
Matavelli et al. (2009) studied this question.
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