Regression of Nephropathy Developed in Diabetes by (Pro)renin Receptor Blockade

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Why the study?

Does (pro)renin receptor blockade inhibit or reverse the progression of nephropathy in diabetic rats?

Structured PICO

Does (pro)renin receptor blockade inhibit or reverse the progression of nephropathy in diabetic rats?

Population

17-week-old heminephrectomized streptozotocin-induced diabetic rats with increased urinary protein excretion and significant glomerulosclerosis

Intervention

(pro)renin receptor blocker (PRRB) administered via subcutaneously implanted osmotic minipumps for 12 weeks

Comparator

Angiotensin-converting enzyme inhibitor (ACEi) or vehicle peptide administered via subcutaneously implanted osmotic minipumps for 12 weeks

Outcome

Progression of nephropathy (urinary protein excretion and glomerulosclerosis)surrogate

(Pro)renin receptor blockade may inhibit progression and reverse existing glomerulosclerosis in diabetic nephropathy models.

No takes yet. Share an insight, caveat, or question.

May inhibit diabetic nephropathy progression in rats; leaves open translation to human kidney disease trials.

Takahashi et al. (2007) studied this question.

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