Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 31, 2006Journal of the American Society of Nephrology

Prorenin Receptor Blockade Inhibits Development of Glomerulosclerosis in Diabetic Angiotensin II Type 1a Receptor–Deficient Mice

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does prorenin receptor blockade prevent diabetic nephropathy in diabetic Angiotensin II type 1a receptor-deficient mice?

Population

Wild-type mice and Angiotensin II type 1a receptor gene-deficient mice with diabetes induced by…

Comparison

Prolonged prorenin receptor blockade with a… vs Prolonged inhibition of angiotensin-converting…

Design

Preclinical

Authors

AIAtsuhiro IchiharaGeneral / Preventive / LipidsFSFumiaki SuzukiTulane UniversityTNTsutomu NakagawaToyonaka Municipal Hospital

Discussion

Loading...

Member takes

Implication

Hypothesis-generating in diabetic mice; leaves open prorenin receptor blockade as an AngII-independent target pending human trials.

Structured PICO

Does prorenin receptor blockade prevent diabetic nephropathy in diabetic Angiotensin II type 1a receptor-deficient mice?

P
Population
Wild-type mice and Angiotensin II type 1a receptor gene-deficient mice with diabetes induced by streptozotocin treatment
I
Intervention
Prolonged prorenin receptor blockade with a short peptide of prorenin
C
Comparator
Prolonged inhibition of angiotensin-converting enzyme
O
Outcome
Development and progression of diabetic nephropathy and mitogen-activated protein kinase (MAPK) activationsurrogate

Prorenin receptor blockade prevents diabetic nephropathy via an AngII-independent mechanism involving MAPK activation, suggesting a novel therapeutic target.

Cite This Study

Ichihara et al. (2006) studied this question.

synapsesocial.com/papers/6a856a8443622fd4ea672559https://doi.org/10.1681/asn.2006010029
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin2002 · 1,281 citations
  2. 2Roles of Renal and Vascular Renin in Spontaneous Hypertension and Switching of the Mechanism Upon Nephrectomy1991 · 48 citations
  3. 3Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes2001 · 6,044 citations
  4. 4Renin Is Expressed in Rat Macrophage/Monocyte Cells1996 · 72 citations
  5. 5Heminephrectomy Causes the Progression of Glomerulosclerosis and Apoptosis in High IgA Strain ddY Mice2002 · 10 citations