Key result
Chronic elevations in circulating native prorenin increased systolic blood pressure (+25 mm Hg) but did not cause cardiac fibrosis or renal glomerular sclerosis in transgenic mice.
Why the study?
Does chronic elevation of circulating prorenin cause cardiac fibrosis or renal glomerular injury in mice?
Population
Transgenic mice with selective increases in circulating native or active site-mutated prorenin
Comparison
Chronic elevation of circulating native or… vs Control animals
Design
Preclinical
Follow-up
up to 18 months
Authors
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Prorenin raises BP without fibrosis in mice; leaves open its direct role in human cardiorenal injury.
Does chronic elevation of circulating prorenin cause cardiac fibrosis or renal glomerular injury in mice?
Chronic elevations in circulating prorenin increase blood pressure via angiotensin II generation but do not directly cause cardiac fibrosis or renal glomerular injury in a mouse model.
Mercure et al. (2009) studied Cardiac fibrosis and renal glomerular sclerosis. Selective increases in circulating native or active site-mutated prorenin vs. Control animals was evaluated on Systolic blood pressure, cardiac fibrosis, and renal glomerular sclerosis. Chronic elevations in circulating native prorenin increased systolic blood pressure (+25 mm Hg) but did not cause cardiac fibrosis or renal glomerular sclerosis in transgenic mice.
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