Combined association of triglyceride–glucose index and systemic inflammation index on all-cause and cardiovascular mortality

Figures

• 

  Fig. 1. Flowchart of the selection strategy. TyG triglyceride–glucose index, SII Systemic Inflammation Index, DM diabetes, CVD cardiovascular disease.

• 

  Fig. 2. Forest plot showing the association of TyG and SII with mortality. This forest plot presents the HRs with 95% CIs for mortality according to TyG and SII levels, using Q1 as the reference group. HR hazard ratio, CI confdence interval, TyG triglyceride–glucose index, SII Systemic Inflammation Index. (A) Association of TyG with the risk of mortality; (B) association of SII with the risk of mortality. The event column represents the number of individuals with positive outcomes.

• 

  Fig. 3. Forest plot showing the association of joint effect with mortality. This forest plot presents the HRs with 95% CIs for mortality,according to the Combined associations of TyG and SII, using the low TyG & low SII group as a reference. HR hazard ratio, CI confdence interval, TyG triglyceride–glucose index, SII Systemic Inflammation Index. The event column represents the number of individuals with positive outcomes.

• 

  Fig. 4. Association of TyG and SII with All-Cause and CVD Mortality using RCS. Restricted cubic spline analysis has four knots. In the RCS analysis, adjustments were made for age, sex, ethnicity, marital status, education level, family income, BMI, smoking status, current alcohol consumption, dyslipidemia, hypertension, and CVD. TyG triglyceride–glucose index, SII Systemic Inflammation Index, BMI body mass index, CVD cardiovascular disease. (A) Association of TyG with the risk of mortality; (B) association of SII with the risk of mortality.

• 

  Fig. 5. Predictive performance of the combined TyG and SII for mortality. The receiver operating characteristic (ROC) curve evaluating the discriminative capabilities by calculating the AUC. AUC area under curve, TyG triglyceride–glucose index, SII Systemic Inflammation Index, CVD cardiovascular disease. (A) Combined association with the All-Cause mortality; (B) Combined association with the CVD mortality.