Key result
Higher TyG index linked to ~16% higher all-cause mortality, particularly in adults under 65.
Why the study?
The impact of age on the association between the triglyceride-glucose index and all-cause and cardiovascular mortality in the general population remains controversial.
Does a higher Triglyceride-glucose (TyG) index predict all-cause and cardiovascular mortality in the general population?
Population
20,194 participants from the National Health and Nutrition Examination Survey (2009-2018)
Comparison
Baseline triglyceride-glucose index levels and comparison with HOMA-IR
Design
Observational cohort study
Follow-up
Median 105 months
Authors
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TyG index may flag higher mortality risk under age 65; leaves open added value for routine risk stratification.
Cohort (n=20,194)
Yes
Does a higher Triglyceride-glucose (TyG) index predict all-cause and cardiovascular mortality in the general population?
Effect estimate: HR 1.160 (95% CI 1.062-1.267)
p-value: p=<0.001
The TyG index is a significant predictor of all-cause and cardiovascular mortality in the general population under 65 years of age, demonstrating superior predictive performance compared to HOMA-IR.
Chen et al. (2023) conducted a cohort in General population (n=20,194). Triglyceride glucose (TyG) index vs. Lower TyG index was evaluated on All-cause mortality (HR 1.160, 95% CI 1.062-1.267, p=<0.001). A higher Triglyceride-glucose (TyG) index was significantly associated with increased all-cause mortality (HR 1.160) in the general population, with the association being particularly robust in individuals aged under 65.
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