Why the study?
The impact of the triglyceride-glucose (TyG) index on mortality in patients with diabetes and hypertension remains unclear.
Is the triglyceride-glucose (TyG) index associated with all-cause and cardiovascular mortality in patients with diabetes mellitus and hypertension?
Population
3296 diabetes patients with hypertension from the National Health and Nutrition Examination Survey
Comparison
Levels of triglyceride-glucose (TyG) index
Design
Retrospective cohort study
Follow-up
Median 82 months (IQR, 44–129)
Key result
The triglyceride-glucose index showed a nonlinear association with mortality, with the risk of all-cause death increasing above an index of 8.9 (HR 1.38; 95% CI 1.14-1.67).
Authors
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TyG index >8.9 was associated with higher mortality; leaves open its added value for risk stratification in diabetes with hypertension.
Cohort (n=3,296)
Yes
Is the triglyceride-glucose (TyG) index associated with all-cause and cardiovascular mortality in patients with diabetes mellitus and hypertension?
Effect estimate: HR 1.38 (95% CI 1.14-1.67)
In patients with diabetes and hypertension, a TyG index above 8.9 is associated with increased all-cause mortality, and above 9.0 with increased cardiovascular mortality, particularly in those under 65 years old.
Zhao et al. (2026) conducted a cohort in Diabetes Mellitus with Hypertension (n=3,296). Triglyceride-glucose (TyG) index vs. TyG index below inflection points (8.9 for all-cause, 9.0 for CV mortality) was evaluated on All-cause mortality (HR 1.38, 95% CI 1.14-1.67). The triglyceride-glucose index showed a nonlinear association with mortality, with the risk of all-cause death increasing above an index of 8.9 (HR 1.38; 95% CI 1.14-1.67).
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