Why the study?
The relationship between the triglyceride-glucose index and cardiovascular mortality risk remains limited and controversial, particularly when accounting for non-cardiovascular mortality as a competing risk.
Does a higher triglyceride-glucose index increase the risk of cardiovascular mortality in populations aged 18-80 years?
Population
23,800 participants aged 18-80 years from NHANES 1999-2018
Comparison
Levels of triglyceride-glucose (TyG) index
Design
Observational cohort study using NHANES data
Key result
The triglyceride-glucose index was positively associated with cardiovascular mortality risk (HR 1.24; 95% CI 1.08-1.41; P=0.0017), with risk intensifying beyond a threshold of 9.4.
Authors
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TyG index was associated with higher cardiovascular mortality beyond 9.4; hypothesis-generating and should not yet change practice.
Cohort (n=23,800)
Yes
Does a higher triglyceride-glucose index increase the risk of cardiovascular mortality in populations aged 18-80 years?
Effect estimate: HR 1.24 (95% CI 1.08-1.41)
p-value: p=0.0017
The TyG index has a non-linear, reversed L-shaped relationship with cardiovascular mortality, with risk significantly increasing when the index exceeds 9.4.
Yao et al. (2025) conducted a cohort in Cardiovascular mortality risk (n=23,800). Triglyceride-glucose index (TyG index) was evaluated on Cardiovascular mortality (HR 1.24, 95% CI 1.08-1.41, p=0.0017). The triglyceride-glucose index was positively associated with cardiovascular mortality risk (HR 1.24; 95% CI 1.08-1.41; P=0.0017), with risk intensifying beyond a threshold of 9.4.
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