Population
Offspring of female mice with chemically induced hypothyroidism
Design
Preclinical
Authors
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May guide mechanistic studies of hypothyroid deafness; leaves open translation to human congenital hearing loss.
This study identifies the epithelium of the inner spiral sulcus as the site of action for thyroxine in the developing organ of Corti, providing a mechanistic basis for congenital deafness in hypothyroidism.
M. S. Deol (1976) studied this question.
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