Why the study?
Does rifampin alone or in combination with other antibiotics improve bone sterilization in rabbits with experimental osteomyelitis?
Population
Rabbits with experimental osteomyelitis
Comparison
Rifampin alone or in combination with… vs Single drug regimens of gentamicin, sisomicin…
Design
Preclinical
Follow-up
14 to 28 days
Authors
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Supports exploration of triple therapy in human osteomyelitis trials; leaves open translation from rabbit models.
Does rifampin alone or in combination with other antibiotics improve bone sterilization in rabbits with experimental osteomyelitis?
In a rabbit model of osteomyelitis, combination therapy with rifampin, sisomicin, and cephalothin was highly effective at sterilizing infected bones, though rifampin use carries a risk of rapid resistance development in treatment failures.
C. W. Norden (1975) studied this question.
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