October 12, 2019European Heart Journal - Cardiovascular ImagingOpen Access

Cardiac perfusion, structure, and function in type 2 diabetes mellitus with and without diabetic complications

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Why the study?

Coronary microvascular disease is a known complication in type 2 diabetes mellitus, prompting investigation into its relationship with diabetic complications, left ventricular function, and structure.

Population

193 patients with T2DM and 25 control subjects

Comparison

T2DM with complications vs uncomplicated T2DM vs controls

Design

Cross-sectional study

Authors

MSMartin Heyn SørensenSlagelse Hospital ABAnnemie Stege BojerHerlev Hospital DBDavid BroadbentUniversity of Leeds

Discussion

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Implication

Supports microvascular dysfunction in T2DM; hypothesis-generating for risk stratification and requires prospective validation.

Structured PICO

Population

218 adults, comprising 193 patients with type 2 diabetes mellitus (T2DM) for at least 3 months (aged 18-80, eGFR ≥30 ml/min/1.73m2) and 25 age- and sex-matched control subjects without T2DM or known coronary artery disease.

Comparator

Age- and sex-matched control subjects without T2DM or known coronary artery disease.

Outcome

Myocardial perfusion reserve (MPR) and left ventricular structure and function (LV mass, E/e*) evaluated by cardiovascular magnetic resonance and echocardiography.surrogate

Type 2 diabetes is associated with reduced myocardial perfusion reserve, which is further impaired in the presence of microvascular complications like albuminuria and retinopathy, and correlates with diastolic dysfunction.

Limitations

Cross-sectional design precludes conclusions on causality.
Presence of epicardial coronary stenosis was excluded by symptoms, LGE, or history rather than routine coronary angiography, potentially missing non-significant stenosis or balanced ischemia.
Higher consumption of ACE-i/ARB in patient groups with diabetic complications compared to uncomplicated diabetes.

Cite This Study

Sørensen et al. (2019) studied this question.

synapsesocial.com/papers/6a82073e1ece0ba82ce1ba9c https://doi.org/10.1093/ehjci/jez266

View Full Paper

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Cardiac perfusion, structure, and function in type 2 diabetes mellitus with and without diabetic complications

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Cardiac perfusion, structure, and function in type 2 diabetes mellitus with and without diabetic complications

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider