Hodgkin's Disease

Article1 August 1967Hodgkin's DiseaseImmunologic, Clinical, and Histologic Features of 50 Untreated PatientsROBERT S. BROWN, M.D., HARLEY A. HAYNES, M.D., H. THOMAS FOLEY, M.D., HERMAN A. GODWIN, M.D., COSTAN W. BERARD, M.D., PAUL P. CARBONE, M.D.ROBERT S. BROWN, M.D., HARLEY A. HAYNES, M.D., H. THOMAS FOLEY, M.D., HERMAN A. GODWIN, M.D., COSTAN W. BERARD, M.D., PAUL P. CARBONE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-2-291 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptImpaired delayed hypersensitivity (1-9) and prolonged skin homograft rejection (8-11) have been demonstrated in patients with Hodgkin's disease, even in those with localized involvement and in good clinical condition. Defective lymphocyte function has been implicated as the cause of the immunologic abnormalities (12-14). In patients with extensive disease, lymphocytopenia may contribute to further impairment (2, 15). A defect in antibody response to primary antigens has been observed, although less consistently than impaired delayed hypersensitivity (5, 16-19). These deficiencies might be responsible for the increased susceptibility of patients with Hodgkin's disease to certain viral and fungal infections (20, 21).In previous...References1. CHASE MW: Delayed-type hypersensitivity and the immunology of Hodgkin's disease, with a parallel examination of sarcoidosis. Cancer Res. 26: 1097, 1966. MedlineGoogle Scholar2. AISENBERG AC: Manifestations of immunologic unresponsiveness in Hodgkin's disease. Ibid., p. 1152. Google Scholar3. AISENBERG AC: Studies on delayed hypersensitivity in Hodgkin's disease. J. Clin. Invest. 41: 1964, 1962. CrossrefMedlineGoogle Scholar4. SCHIER WW: Cutaneous anergy and Hodgkin's disease. New Eng. J. Med. 250: 353, 1954. CrossrefMedlineGoogle Scholar5. 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CALCIATIFAZIO AM: Delayed anergy in Hodgkin's disease. Panminerva Med. 6: 156, 1964. MedlineGoogle Scholar32. LEVINMCDONOUGHMILLERSOUTHAM AGEFDGCM: Delayed hypersensitivity response to DNFB in sick and healthy persons. Ann. N. Y. Acad. Sci. 120: 400, 1964. CrossrefMedlineGoogle Scholar33. ROTTINOHOFFMANN AGT: Studies of immunological reactions of patients with Hodgkin's disease: the tuberculin reaction. Amer. J. Med. Sci. 220: 662, 1950. CrossrefMedlineGoogle Scholar34. TRUBOWITZMASEKDEL ROSARIO SBA: Lymphocyte response to phytohemagglutinin in Hodgkin's disease, lymphatic leukemia and lymphosarcoma. Cancer 19: 2019, 1966. CrossrefMedlineGoogle Scholar35. ULTMANNCUNNINGHAMGELLHORN JEJKA: The clinical picture of Hodgkin's disease. Cancer Res. 26: 1047, 1966. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT S. BROWN, M.D.; HARLEY A. HAYNES, M.D.; H. THOMAS FOLEY, M.D.; HERMAN A. GODWIN, M.D.; COSTAN W. BERARD, M.D.; PAUL P. CARBONE, M.D.Affiliations: Bethesda, MarylandFrom the Medicine, Dermatology, Radiation, and Pathologic Anatomy Branches, National Cancer Institute, National Institutes of Health, Bethesda, Md.This work was presented in part at the 58th Annual Meeting of the American Association for Cancer Research, April 13, 1967, Chicago, Ill.Requests for reprints should be addressed to Robert S. Brown, M.D., Medicine Branch, National Cancer Institute, Bldg. 10, Room 12N228, National Institutes of HealthBethesda, Md. 20014. 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THOMAS, M.D., RALPH E. JOHNSON, M.D., PAUL P. CARBONE, M.D., HARLEY A. HAYNES, M.D. 1 August 1967Volume 67, Issue 2Page: 291-302KeywordsAntibody productionAntigensDermatologyHodgkin lymphomaHomograftsHypersensitivityInfectious diseasesLymphocytesLymphopenia ePublished: 1 December 2008 Issue Published: 1 August 1967 PDF downloadLoading ...